A world-wide yearly survey of new data and trends in adverse - download pdf or read online

By J.K. Aronson (Eds.)

ISBN-10: 0444509992

ISBN-13: 9780444509994

The uncomfortable side effects of substances Annual was once first released in 1977. it's been released regularly due to the fact then, as a each year replace to the encyclopaedic quantity Meyler's negative effects of gear. every one new Annual presents clinicians and scientific investigators with a competent and important every year survey of recent facts and traits within the region of inauspicious Drug Reactions and Interactions.

a global staff of experts have contributed to the Annuals by means of picking out seriously from every one year's guides all that's really new and informative, by way of seriously analyzing it, and by means of stating no matter what is deceptive. using the e-book is superior by way of separate indexes, permitting the reader to go into the textual content through the drug identify, opposed influence, or drug interaction.

exact positive aspects of the Annuals are the unwanted side effects of substances Essay, often written by means of a visitor writer, and the exact reports: brief articles, in the diverse chapters, that supply additional recognition to issues of present interest.

The Essay in Annual 26 is entitled 'How secure is cannabis?' (by Professor L.L. Iversen) and there's a old Essay entitled 'From thalidomide to pharmacovigilance: a private account' (by Professor D.J. Finney).

The unique stories during this quantity contain, between others:

  • The cognitive results of Ecstasy
  • Antipsychotic medicinal drugs and weight gain
  • Vigabatrin-related visible abnormalities
  • Managing the hostile results of morphine
  • The cardiotoxic results of antihistamines
  • Inhaled corticosteroids and development inhibition in children
  • Bioterrorism and its prevention via immunization

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Extra resources for A world-wide yearly survey of new data and trends in adverse drug reactions

Sample text

This was also supported by the failure to detect any genetic toxicity in other tests designed to identify drugs capable of causing chromosomal damage. For example, THC was negative in the so-called “Ames test”, in which bacteria are exposed to very high concentrations of a drug to see whether it causes mutations. In another test, hamster ovary cells were exposed to high concentrations of the drug in tissue culture; there were no effects on cell division that might suggest chromosomal damage. By any standards, THC must be considered to be very safe, both acutely and during longterm exposure.

Finney DJ. Drugs, adverse reactions, and patients. In: Gent M, Shigematsu I (editors). Epidemiological Issues in Reported Drug-Induced Illnesses—SMON and Other Examples. Hamilton, Ontario: McMaster University Library Press, 1978: 311–18. 29. Andrew JE, Prescott P, Smith TMF, Inman WHW, Kubota K. Testing for adverse reactions using Prescription Event Monitoring. Stat Med 1996; 15: 987–1002. 30. Napke E. Drug Adverse Reaction Alerting Program. Can Pharm J 1968; 29: 251–4. 31. Patwary KW. Report on Statistical Aspects of the Pilot Project for International Drug Monitoring.

Although claims were made that exposure of a small number of rhesus monkeys to cannabis smoke led to ultrastructural changes in the septum and hippocampus (48E , 49E ), subsequent larger-scale studies failed to show any cannabis-induced histopathology in monkey brain (50E ). Studies of the effects of cannabinoids on neurons in vitro have also yielded inconsistent results. Exposure of rat cortical neurons to THC shortened their survival: twice as many cells were dead after exposure to THC 5 µmol/l for 2 h than in control cultures (51E ).

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A world-wide yearly survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)


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