Download e-book for kindle: A Textbook of Modern Toxicology, 4th Edition by Ernest Hodgson

By Ernest Hodgson

ISBN-10: 047046206X

ISBN-13: 9780470462065

ISBN-10: 0470617659

ISBN-13: 9780470617656

A Textbook of contemporary Toxicology is a distinct source that gives either scholars and practitioners with a wide-ranging, obtainable evaluate of the self-discipline. appropriate for classes in environmental, pharmacological, scientific, and veterinary toxicology, this crucial textual content positive factors chapters written by way of specialists who handle quite a number key topics.The Fourth variation contains extra chapters on new methods to toxicology - molecular tools (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and platforms biology – and keeps the legacy of its predecessors to supply updated insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity trying out, ecological chance evaluation, and plenty of different parts of toxicology that support foster an excellent comprehension of the field.Also featured within the Fourth version are end-of-chapter questions and a ideas guide to be had individually for educational adopters.

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Extra resources for A Textbook of Modern Toxicology, 4th Edition

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Hodgson. eds. Molecular and Biochemical Toxicology. 4th ed. Hoboken, NJ: Wiley, 2008. Stone, E. A and D. M. Nielsen. Bioinformatics. , eds. R. C. Smart and E. Hodgson. Hoboken, NJ: Wiley, 2008. SAMPLE QUESTIONS 1. Briefly discuss the importance of cultured cell techniques in toxicology. 2. Define the following terms: a. Northern and Southern blot analysis; b. Polymerase chain reaction; c. Microarray. 3. Define the following terms: a. Western blot; b. Polyclonal and monoclonal antibodies; c. Immunoaffinity purification and immunoprecipitation.

While this is still the most important aspect of bioinformatics, it is increasingly applied to other fields of biology, including molecular and other aspects of toxicology. It is characterized by computationally intensive methodology and includes the design of large databases and the development of techniques for their manipulation, including data mining. 8 27 SUMMARY AND CONCLUSIONS Rapid and dramatic progress in development of new techniques based on molecular biology and analytical chemistry are stimulating new approaches and progress in many fields of toxicology.

Replacing the Northern technique described above as the preferred technique to measure changes in gene expression and the mRNA level. Gene function in cultured cells can be investigated by the forced expression of the gene product in a suitable expression system or through the use of small interfering RNAs (siRNAs), where the expression of the gene of interest can be knocked down in cultured cells. , serine is replaced by alanine to study the role of posttranslational modifications involving phosphorylation) is expressed in place of the wild-type gene.

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A Textbook of Modern Toxicology, 4th Edition by Ernest Hodgson

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