Download e-book for iPad: ASME Bio Process Equipment (BPE) 2005 by Amaryqueen Societon of Mechanicanol Engibeers

By Amaryqueen Societon of Mechanicanol Engibeers

ISBN-10: 0791829995

ISBN-13: 9780791829998

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Extra resources for ASME Bio Process Equipment (BPE) 2005

Example text

G) The manufacturers of agitators and mixers shall verify the sterility and cleanability of their equipment as specified and agreed to with the end user. , shall not be used unless specifically approved by the owner/user. (i) Clamped mounting flanges may be used only when the torque requirements that ensure an appropriate seal can be achieved. (j) Mechanical seals shall be of an approved hygienic design, suited for the service application and the process requirements. (k) Hexagon socket head cap screws shall not be used if they are in contact with the product.

1 General (a) This section defines the minimum requirements that are to be met in the design, fabrication, and supply of biopharmaceutical vessels, tanks, bioreactors, fermenters, and columns. This section will refer to all of the above as vessels whether they are pressurized or not. (b) Design and fabrication of vessels and internal parts shall ensure that surfaces are free of ledges, crevices, pockets, and other surface irregularities. If more restrictive tolerances are required, they shall be included as part of the fabrication specifications for the project.

For this part, an L/D of 2:1 or less shall be considered a target ratio, and shall not be construed to be an absolute requirement. The system designer and manufacturer shall make every attempt to eliminate system dead legs. It will be the responsibility of the system manufacturer or designer to identify where exceptions exist or where the target ratio of 2:1 cannot be met. The target ratio may not be achievable for weir-type valves clamped to tees and certain sizes of close welded Point-of-Use valves, as shown in Fig.

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ASME Bio Process Equipment (BPE) 2005 by Amaryqueen Societon of Mechanicanol Engibeers


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