New PDF release: Biochemistry and Molecular Biology of Antimicrobial Drug

By Trevor J. Franklin, George Alan Snow

ISBN-10: 0412821907

ISBN-13: 9780412821905

ISBN-10: 9401091277

ISBN-13: 9789401091275

The speedy advances made within the research of the synthesis, constitution and serve as of organic macromole­ cules within the final fifteen years have enabled scientists all in favour of antimicrobial brokers to accomplish a substantial degree of figuring out of ways those elements inhibit mobilephone development and department. using antimicrobial brokers as hugely particular inhibitors has in flip considerably assisted the research of advanced biochemical techniques. The literature during this box is so wide, even if, that we thought of an try out can be made to attract jointly in an introductory booklet the extra major experiences of modern years. This booklet, that is in reality in accordance with lecture classes given through us to undergraduates at Liverpool and Manchester Universities, is consequently meant as an advent to the biochemistry of antimicrobial motion for complex scholars in lots of disciplines. we are hoping that it will possibly even be important to verified scientists who're new to this quarter of analysis. The e-book is worried with a dialogue of medically very important antimicrobial compounds and likewise a few brokers that, even supposing having no clinical makes use of, have proved valuable as examine instruments in bio­ chemistry. Our objective has been to give the on hand details in an easy and readable method, empha­ sizing the verified evidence instead of extra debatable fabric. each time attainable, notwithstanding, we've indicated the gaps within the current wisdom of the topic the place extra info is required.

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Extra info for Biochemistry and Molecular Biology of Antimicrobial Drug Action

Sample text

Isoniazid has long been known to be metabolically unstable in mycobacteria due to the activity of a unique mycobacterial catalase-peroxidase encoded by the katG gene. 18) being the major product. This two-stage concept of the mechanism of action of isoniazid is strengthened by the existence of two forms of mycobacterial resistance to the drug. One type of mutant has a defective katG gene that precludes the conversion of the prodrug to its active form. The second resistant phenotype depends on an isoniazid-resistant variant of InhA, characterized by a markedly lower affinity for NADH which minimizes the attack of the isoniazid metabolite on the enzyme.

Their only serious defects include their ability to cause immunologic sensitization in a small proportion of patients, a side effect which prevents their use in those affected, and the frequency of emergence of bacteria resistant to [3-lactams. The original penicillins isolated directly from mould fermentations were mixtures of compounds having different side chains. 14). The first successful variant was obtained by replacing phenylacetic acid by phenoxyacetic acid as the added precursor. 14). The main advantage of this change was an improvement in the stability of the penicillin towards acid.

Et al. (1996). Structure of UDP-N-acetyl glucosamine enol pyruvyl transferase: an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetyl glucosamine and the drug fosfomycin. Structure 4, 1465-74. 1 Microbe killers: antiseptics and disinfectants The major interest throughout this book lies in the mechanism of action of drugs that can be used against microbial infections.

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Biochemistry and Molecular Biology of Antimicrobial Drug Action by Trevor J. Franklin, George Alan Snow


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