By Richard A Anderson, Norah Spears DPhil BSc(Hons)
Cancer remedy and the Ovary: scientific and Laboratory research of Ovarian Toxicity provides the reader with a uncomplicated knowing on how the ovary is adversely impacted by way of melanoma remedy, a vital foundational wisdom for this rapidly-developing box.
The e-book describes either the medical and laboratory techniques to studying the doubtless adversarial results of melanoma remedy at the ovary, additionally laying out attainable preventative methods and destiny instructions for the sphere.
Clinicians operating within the box of reproductive biology and oncology will locate a vital reference that offers the required instruments to evaluate the reproductive toxicological results of melanoma treatments.
- Brings jointly a world workforce of specialists to deal with the present nation of the technological know-how of ovarian toxicity attributable to melanoma remedy
- Provides medical, medical, and preclinical ways to assessing this toxicity
- Describes present thoughts and destiny concepts to guard the ovary
- Ideal reference for the additional examine of ovarian toxicity, oncofertility, melanoma remedy, and reproductive toxicology
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Additional resources for Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity
Cancer Biol Ther. 2003;2(4 suppl 1):S2ÀS4. 16. Payne S, Miles D. Mechanisms of anticancer drugs. In: Gleeson M, ed. In Scott-Brown’s Otorhinolaryngology: Head and Neck Surgery. 7th ed. London: Hodder Arnold; 2008:34À46. 17. Zhao XJ, Huang YH, Yu YC, Xin XY. GnRH antagonist cetrorelix inhibits mitochondriadependent apoptosis triggered by chemotherapy in granulosa cells of rats. Gynecol Oncol. 2010;118(1):69À75. 18. Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer.
Several studies have subsequently confirmed reduced AMH in survivors of adult and childhood cancer, with some of these finding clear relationships between the degree of loss of AMH and the gonadotoxicity of the treatment involved. 23 AMH has also been used to show the marked gonadotoxicity of radiotherapy involving the ovaries. In general, comparable data have been obtained using AFC,15,20,27,28 although the literature on this is substantially sparser. 2 Prospective Analyses There are now a growing number of studies that have prospectively assessed AMH as a marker of gonadotoxicity, thus making it possible to use pretreatment samples to show the fall in AMH in individuals, rather than requiring age-matched controls.
FSH is clearly of value in diagnosing the menopause or POI, but it is of lesser value in detecting women of a low ovarian reserve. This is to be expected given its physiological role in selection of the dominant follicle and the later stages of antral follicle growth, thus being central to the ovulatory function of the ovary rather than the regulation of the early stages of follicle growth. Current interest focuses around the use of measurement of circulating anti-Müllerian hormone (AMH), and ultrasound assessment of the number of small (generally 2À10 mm diameter) antral follicles: the antral follicle count (AFC).
Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity by Richard A Anderson, Norah Spears DPhil BSc(Hons)