By Curtis Klaassen
The such a lot depended on all-in-one evaluation of the biomedical and environmental points of toxicology--NOW extra whole, updated, and in complete color
A Doody's middle name for 2015!
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretationof the elemental elements of toxicology featured during the textual content
- EXPANDED tables, illustrations, and different visuals areupdated with state of the art criteria that makes thisedition much more present and suitable
- DVD with photograph financial institution positive aspects all tables and illustrations from the textual content in presentation-ready structure
- NEW CHAPTERS contain "Toxic results of Calories"and "Toxic results of Nanoparticles"
The world's major and such a lot authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever earlier than. Now in complete colour, and punctiliously revised, the 8th variation of Casarett & Doull's TOXICOLOGY: the elemental technological know-how of Poisons not just promises a finished evaluate of the basic parts of toxicology, it deals the main up-to-date,revealing, and in-depth examine the systemic responses of poisonous substance on hand anywhere.
Combined with the newest pondering by means of the field's most excellent students plus sturdy assurance of normal rules, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the traditional for toxicology references.
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Additional info for Casarett and Doull's toxicology
The “vehicle” (the material in which the chemical is dissolved) and other formulation factors can markedly alter absorption after ingestion, inhalation, or topical exposure. In addition, the route of administration can influence the toxicity of agents. For example, an agent that is detoxified in the liver would be expected to be less toxic when given via the portal circulation (oral) than when given via the systemic circulation (inhalation). Occupational exposure to toxic agents most frequently results from breathing contaminated air (inhalation) and/or direct and prolonged contact of the skin with the substance (dermal exposure), whereas accidental and suicidal poisoning occurs most frequently by oral ingestion.
The abscissa is a log dosage of the chemical. In the top panel the ordinate is mortality frequency, in the middle panel the ordinate is percent mortality, and in the bottom panel the mortality is in probit units (see text). uals; this is known as biological variation. Animals responding at the left end of the curve are referred to as hypersusceptible, and those at the right end of the curve are called resistant. If the numbers of individuals responding at each consecutive dose are added together, a cumulative, quantal dose–response relationship is obtained.
Chronic toxic effects may occur, therefore, if the chemical accumulates in the biological system (rate of absorption exceeds the rate of biotransformation and/or excretion), if it produces irreversible toxic effects, or if there is insufficient time for the system to recover from the toxic damage within the exposure frequency interval. For additional discussion of these relationships, consult Chaps. 5 and 7. 2996R_ch02_011-016 4/11/01 9:35 AM Page 15 CHAPTER 2 PRINCIPLES OF TOXICOLOGY 15 Figure 2-2.
Casarett and Doull's toxicology by Curtis Klaassen