By Jim E. Riviere
Now in a revised version, Comparative Pharmacokinetics: ideas, thoughts, and functions offers the foundations and methods of comparative and veterinary pharmacokinetics in a close but sensible demeanour. built as a device for making sure that pharmacokinetics reports are competently designed and properly interpreted, the publication presents whole insurance of the conceptual foundation of pharmacokinetics as used for quantifying organic procedures from the views of body structure and medicine. New chapters were further on quantitative constitution permeability relationships and bioequivalence, and a couple of current chapters were considerably revised and multiplied to supply a present source for veterinary and comparative pharmacokinetics.
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Extra resources for Comparative Pharmacokinetics: Principles, Techniques and Applications
2011 Jim E. Riviere. Published 2011 by John Wiley & Sons, Inc. ISBN: 978-0-813-82993-7 39 40 Comparative Pharmacokinetics Food Lacrimal Duct Buccal Cavity Salivary Gland Nasal Passage Esophagus Trachea Stomach Small Intestine Duodenum Jejunum Ilium Bile Duct Large Intestine Rectum FECES Fig. 1 Functional structure of the gastrointestinal tract. best conceptualized as actually being part of the external environment, which, in contrast to the skin, is protected and whose microenvironment is closely regulated by the organism.
In an oral absorption scenario, this would equate to dissolution and solubility. In contrast, for a drug with low intrinsic permeability, absorption or movement into tissue will not be dependent on the mass available for transfer, its solubility in an oral absorption context, but rather its permeability will dictate amount absorbed. Both these scenarios illustrate rate-limiting processes involved in drug disposition and, as will be seen, are major determinants of the pharmacokinetic properties of a drug and/or its formulation.
QSAR Combinatorial Science. 28:1478–1486. E. 2007. A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures. SAR and QSAR Environmental Research. 18:579–593. E. 2010. An index for characterization of nanomaterials in biological systems. Nature Nanotechnology. 5:671–675. 4 Absorption Absorption is the movement of drug from the site of administration into the blood. There are a number of methods available for administering drugs to animals.
Comparative Pharmacokinetics: Principles, Techniques and Applications by Jim E. Riviere