Read e-book online Controlled drug delivery PDF

By Stephen D Bruck

ISBN-10: 0849351812

ISBN-13: 9780849351815

ISBN-10: 0849351820

ISBN-13: 9780849351822

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2014) based on the CM-Starch excipient able to form an inclusion complex with the oil and to generate stable structures using a powder or tablet matrix that can control omega-3 delivery. , 2010). The helical structure of CM-Starch was considered a key element allowing stabilization of omega-3 and its release in intestinal fluid. , 2013) suggested that omega-3 oils including diglyceride and triglyceride forms were mostly incorporated into the single helix V-form of CM-Starch. The X-ray diffraction analysis showed that omega-3 can play an important role in enhancing the order degree for the CM-Starch matrix.

It is worth mentioning the differences between bound water and free water molecules in starch composition and, more generally, in hydrophilic polymers. Bound water is intrinsically linked via hydrogen bridges to hydroxylic groups of polysaccharide chains, and it is intimately built into the amylose structure (Eisenhaber and Schulz, 1992; Wu and Sarko, 1978a,b). 5 Molecular lipophilicity patterns for Vh-amylose and A double-helical form (blue, hydrophilic surface regions; yellow-brown, hydrophobic areas).

Amylose is also involved in gel and film-forming phenomena, which are related to self-association of its chains. This self-assembling is also responsible for retrogradation on cooling and storage. , fatty acids, plasticizers). , 1990). Many modifications are performed to modulate starch properties and to obtain specific functionalities. These modifications can involve a physical processing (variation of key parameters such as temperature range and heating speed, solids concentration, cooling and drying procedure) or chemical reactions (cross-linking, acetylation, carboxymethylation, hydroxyethylation, oxidation, and partial hydrolysis) or enzymatic degradation.

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Controlled drug delivery by Stephen D Bruck

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