By Neville N. (ed.) Osborne
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Extra info for Current Aspects of the Neurosciences: Volume 3
Mahan, L. C. and Sibley, D . R. (1989). Multiple D2 dopamine receptors produced by alternative splicing. Nature, 342, 926-929 Mulle, C. -P. (1990). A novel type of nicotinic receptor in the rat central nervous system characterized by patch-clamp techniques. 1. , Barton, A . J . , Harrison, P. J. , Heffernan, J. and Pearson, R. C. A. (1989). Messenger RNA encoding the D2 dopamine receptor detected by in situ hybridization histochemistry in rat brain. , Couturier, S. and Ballivet, M. (1988). Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors.
The first is the demonstration of a diversity of receptors much larger than suspected. This concept has already been formulated by those directly involved in the cloning of the various receptors, but it is confirmed and extended by ISHH results. The example we have provided is that of dopamine 02 receptors, where the receptors cloned to date do not, in our opinion, account for all the recognized 02 sites visualized using different ligands. A second aspect of this problem is the clear inadequacy of the tools, ligands and antibodies at present available to account for the different possible receptors deduced from cloning studies.
Brain Res. , 222, 285-307 Palacios, J. , Young, W. S. III and Kuhar, M. J. (1980). Autoradiographic localization of -y-aminobutyric acid (GABA) receptors in the rat cerebellum. Proc. Natl Acad. Sci. USA, 77, 670-674 Parascandola, J. (1980) . Origins of the receptor theory. Trends Pharmacol. Sci. , 1, 189-192 Peralta, E . , Winslow, J. , Smith, D. , Ramachandran,J. and Capon, D. J. (1987a). Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.
Current Aspects of the Neurosciences: Volume 3 by Neville N. (ed.) Osborne