By U.A. Meyer, Jean-Michel Metry, Urs B. Meyer
This important paintings comprehensively covers all problems with drug routine compliance. In 3 sections--Clinical Trials, sufferer administration, and destiny Aspects--it bargains with an issue of discussion and curiosity.
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Extra resources for Drug regimen compliance : issues in clinical trials and patient management
The results of the routine treatment group may lead to higher dosages and/or additional drug prescriptions. e. by fully compliant people). This effect measure has been called ‘method effectiveness’. Currently, as ITT analyses are the rule, only the use effectiveness data are provided, neglecting varying treatment exposures. Rational decision-making, however, calls for additional data about method effectiveness. ITT ANALYSIS The ITT analysis compares the outcomes of groups gained by random allocation irrespective of whether the treatments have been administered according to the study protocol.
Thus, feedback mechanisms, if there are any, can be properly assessed and used for the joint interpretation of compliance and outcome data. ), technical details should be kept as similar as possible across treatment and control groups, unless the use of different modes of presentation is one of the research questions. Finally, one should try to find out the reasons for partial compliance, either by interview or self-administered questionnaires. This provides important information on how to use and interpret compliance data in the context of outcome analysis.
1999 John Wiley & Sons Ltd. ’ Poor compliance may have been negligible or even beneficial for centuries, as long as almost no pharmacologically effective therapies were available. However, since the early days of the use of antibiotics, such as streptomycin, isoniazid, and penicillin, compliance has become an important issue of effective patient care4. Correct prescribing specifies the medicine, type of preparation, dosage, time, regularity, and method of application. g. take before or after meals, avoid intake with dairy products).
Drug regimen compliance : issues in clinical trials and patient management by U.A. Meyer, Jean-Michel Metry, Urs B. Meyer