By Brian A. Callingham
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Additional info for Drugs and Transport Processes: A Symposium
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At similar dose levels delayed toxic effects in the rat kidney are observed with the nondiuretic mercurials (Bowman & Landon, 1967). The membrane effects of diuretic mercurial agents have been extensively studied in the rat kidney (Bowman & Landon, 1967). When these compounds are administered in vivo and tissue slices are prepared and incubated the following ensues: (a) the passive outflow of potassium from kidney tissue is impaired; (b) the active metabolic maintenance of tissue potassium is impaired and sodium-potassium-dependent ATPase activity of the plasma membrane associated with this process is depressed; (c) the maintenance of cell volume is impaired.
Drugs and Transport Processes: A Symposium by Brian A. Callingham